Saccharin and Its Salts
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چکیده
Saccharin Chem. Abstr. Serv. Reg. No.: 81-07-2 Deleted CAS Reg. Nos: 474-91-9; 61255-27-4; 126987-83-5 Chem. Abstr. Name: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide IUPAC Systematic Name: 1,2-Benzisothiazolin-3-one, 1,1-dioxide Synonyms: Acid saccharin; anhydro-ortho-sulfaminebenzoic acid; 3-benzisothiazolinone 1,1-dioxide; benzoic sulfimide; benzoic sulphinide; benzosulfimide; benzosulfinide; ortho-benzoic acid sulfimide; ortho-benzoic sulfimide; ortho-benzosulfimide; ortho-benzoyl sulfimide; 1,2-dihydro-2-ketobenzisosulfonazole; 2,3-dihydro-3-oxobenzisosulfonazole; 1,1-dioxo-1,2-benzisothiazol-3(2H)-one; 3-hydroxybenzisothiazole-S,S-dioxide; saccharimide; saccharin acid; saccharin insoluble; saccharine; saccharinol; saccharinose; saccharol; ortho-sulfobenzimide; ortho-sulfobenzoic acid imide
منابع مشابه
Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients.
Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.
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Sodium saccharin, ascorbate and other sodium salts fed at high doses to rats produce urinary bladder urothelial cytotoxicity with consequent regenerative hyperplasia. For sodium salts that have been tested, tumor activity is enhanced when administered either alone or after a brief exposure to a known genotoxic bladder carcinogen. These sodium salts alter urinary composition of rats resulting in...
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The chemical stimuli of special significance to taste are sugars (sweet), amino acids (umami), sodium chloride and other salts (salty), alkaloids (bitter) and acids (sour). Sugars and amino acids tend to be preferred, while alkaloids and acids tend to be avoided. Intake of salts depends on electrolyte balance. The gustatory system codes taste qualities and their associated hedonic attributes. T...
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Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition, these substances increase urothelial proliferation in short term assays in r...
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Gurmarin (10 microg/ml), a protein extracted from Gymnema sylvestre, depressed significantly (40-50%) the phasic taste responses to sugars (sucrose, fructose, lactose, and maltose) and saccharin sodium recorded from the greater superficial petrosal nerve (GSP) innervating palatal taste buds in the rat. However, no significant effect of gurmarin was observed for taste responses to NaCl, HCl, and...
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